Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Repair After Ischemic Stroke.

• Tác giả: Jennifer An, S Thomas Carmichael, Robert Damoiseaux, Marlesa I Godoy, Jason D Hinman, Yutaro Komuro, Jennifer Putman, Brian Toh, Jack T Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 784.190288 General principles, musical forms, instruments
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683607

Tóm tắt

Axonal degeneration is a core feature of ischemic brain injury that limits functional recovery (1). The pro-degenerative molecule Sarm1 is required for Wallerian axon degeneration after traumatic and chemotoxic nerve injuries (2), however it is unclear if a similar mechanism mediates axonal degradation after ischemic injury. Here we show that loss of Sarm1 results in profound attenuation of axonal degeneration after focal ischemia to the subcortical white matter. Moreover, absence of Sarm1 significantly promotes the survival of neurons remote from but connected to the infarct after ischemic injuries to the subcortical white matter as well as to the cortex. To further understand the mechanism of