Nitric Oxide Inhibition of Glycyl Radical Enzymes and Their Activases.

• Tác giả: Juan Carlos Cáceres, Brandon L Greene, Nathan G Michellys
• Ngôn ngữ: eng
• Ký hiệu phân loại: 598.9 *Falconiformes, Strigiformes, Caprimulgiformes
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683616

Tóm tắt

Innate immune response cells produce high concentrations of the free radical nitric oxide (NO) in response to pathogen infection. The antimicrobial properties of NO include non-specific damage to essential biomolecules and specific inactivation of enzymes central to aerobic metabolism. However, the molecular targets of NO in anaerobic metabolism are less understood. Here, we demonstrate that the