β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.

• Tác giả: Dina Alter, Brandon I Apresa, James R Byrnes, Jesseca M Chung, Carlo Condello, Jaeda C Coutinho-Budd, Lea T Grinberg, Ankit Gupta, Brandon B Holmes, Martin Kampmann, Sarah K Kaufman, Kaan S Kumru, Kevin K Leung, Alissa L Nana, Indigo V L Rose, William W Seeley, Salvatore Spina, Jaime Vaquer-Alicea, Thaddeus K Weigel, James A Wells, Yun Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.13336 Aerospace engineering
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683622

Tóm tắt

To elucidate the impact of Aβ pathology on microglia in Alzheimer's disease pathogenesis, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human microglia upregulate Glypican 4 (GPC4), a GPI-anchored heparan sulfate proteoglycan (HSPG). In a