CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.

• Tác giả: Mohammad Owais Ansari, Zarema Arbieva, Mark Maienschein-Cline, Asrar B Malik, Viswanathan Natarajan, Chinnaswamy Tiruppathi, Dong-Mei Wang, Juan Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 551.423 Barrier islands
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683672

Tóm tắt

The expression of endothelial-enriched receptor tyrosine kinase Tie2 and vascular endothelial cadherin VE-cadherin in endothelial cells (EC) is essential for maintaining endothelial barrier integrity and vascular homeostasis. The Ets family of transcription factors plays a critical role in regulating the expression of Tie2 and VE-cadherin in EC. However, the transcriptional regulation of these factors remains poorly understood. In this study, we performed whole genome methylation analysis and found that the gene encoding the Ets family transcription factor Elf2/Nerf2 was hypermethylated in Camkkβ-deficient (