Optical genome and epigenome mapping of clear cell renal cell carcinoma.

• Tác giả: Jasline Deek, Benjamin Dekel, Yuval Ebenstein, Eitan Friedman, Yehudit Gnatek, Assaf Grunwald, Sivan Louzoun-Zada, Sapir Margalit, Yael Michaeli, Gil Nifker, Dorit Omer, Yuval Scher, Leonie Schütz, Zuzana Tulpová, Elmar Weinhold, Tahir Detinis Zur
• Ngôn ngữ: eng
• Ký hiệu phân loại: 599.26 *Peramelina (Bandicoots)
• Thông tin xuất bản: England : NAR cancer , 2025
• Bộ sưu tập: NCBI
• ID: 683773

Tóm tắt

Cancer cells display complex genomic aberrations that include large-scale genetic rearrangements and epigenetic modulation that are not easily captured by short-read sequencing. This study presents a novel approach for simultaneous profiling of long-range genetic and epigenetic changes in matched cancer samples, focusing on clear cell renal cell carcinoma (ccRCC). ccRCC is a common kidney cancer subtype frequently characterized by a 3p deletion and the inactivation of the von Hippel-Lindau (