BACKGROUND: Ulcerative colitis (UC), a chronic and challenging condition, necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications. Traditional Chinese medicine (TCM), known for its multi-stage and multi-targeted approach, has a long history in treating gastrointestinal diseases and offering a promising alternative UC treatment. AIM: To investigate the key constituents and biological pathways through which METHODS: Network pharmacology investigated the UC-alleviating mechanism of RESULTS: By integrating and analyzing the targets of CONCLUSION: PD alleviates colitis and aids intestinal barrier repair, partly