The misfolding and aggregation of alpha-synuclein play a pivotal role in the pathogenesis of Parkinson's disease (PD), contributing to neuronal dysfunction, the formation of Lewy bodies, and the manifestation of motor symptoms characteristic of PD. Understanding these molecular mechanisms is imperative for advancing therapeutic strategies for this neurodegenerative disorder. Current treatment modalities primarily involve dopamine replacement drugs, which fail to halt or slow disease progression. This study employs in-silico methods, including molecular docking and molecular dynamics simulations, to comprehensively evaluate naturally derived phytochemicals (