Septo-optic dysplasia (SOD) is a congenital disorder characterized by a triad of ophthalmologic, neurologic, and hypothalamic-pituitary developmental dysfunctions. This case describes a 25-year-old woman with SOD and multiple associated endocrinopathies, including diabetes insipidus, who presented to the hospital after running out of subcutaneous desmopressin that was adequately controlling her diabetes insipidus. Her family expressed concerns about the standard intranasal formulation due to a history of adverse effects. The endocrinology team developed a tailored treatment plan to address the family's needs and limitations. This case highlights the role of endocrinologists in managing this rare disorder and the importance of tailored treatment plans for patients with complex needs.