Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy. Despite these interventions, persistent infection required an Eloesser flap procedure for enhanced drainage. This case underscores the importance of early diagnosis and aggressive, multidisciplinary treatment approaches, including surgery and antifungal therapy, to improve outcomes in immunocompromised patients facing this life-threatening condition.