A Perplexing Case Highlighting the Diagnostic Conundrum of Miliary Tuberculosis Mimicking Sarcoidosis and Progressing Into Hemophagocytic Lymphohistiocytosis.

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Tác giả: Alexa Constantakos, Ivonne De La Hoz, George Everett, Dwayne Gordon, Weiying Li, Edward Maharam, Prachi Mann

Ngôn ngữ: eng

Ký hiệu phân loại: 616.995 Tuberculosis

Thông tin xuất bản: United States : Cureus , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 684098

Establishing the diagnosis of miliary tuberculosis (TB) can be challenging due to the heterogeneous clinical presentations and low sensitivity of diagnostic tests. Miliary TB shares overlapping clinical, radiological, and histopathological features with other chronic granulomatous diseases, such as sarcoidosis, often posing a significant diagnostic challenge for clinicians. A 36-year-old male from Haiti presented with a four-month history of recurrent fever, dry cough, night sweats, and weight loss. Chest imaging revealed innumerable widespread miliary nodules throughout the lungs bilaterally, raising a high clinical suspicion for miliary TB. The work-up for bacterial, fungal, and viral infection was negative, and there was no evidence of malignancy. Surprisingly, extensive TB testing yielded negative results. The interferon-gamma release assay (QuantiFERON TB Gold Plus®),
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