The ongoing Guillain-Barré syndrome (GBS) outbreak in Pune, India, has raised significant concerns among public health administrators at both the state and central government levels. Over a hundred cases of GBS have been reported in the region, with some patients being treated in the intensive care unit (ICU) and receiving mechanical ventilation. This outbreak has already resulted in one fatality, and new cases continue to emerge. There is growing concern over a potential rise in cases and the possible spread to other areas. Although GBS is a noncommunicable disease, it is crucial to raise awareness about its causes, clinical features, and treatment and management to mitigate morbidity and mortality associated with this condition.