Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system.

• Tác giả: Ying An, Tao Dong, Xiaoye Liang, Tong-Tong Pei, Wenming Qin, Dora Yuping Wang, Zeng-Hang Wang, Ting Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 684230

Tóm tắt

Peptidoglycan (PG) serves as an essential target for antimicrobial development. An overlooked reservoir of antimicrobials lies in the form of PG-hydrolyzing enzymes naturally produced for polymicrobial competition, particularly those associated with the type VI secretion system (T6SS). Here, we report that a T6SS effector TseP, from