In Vitro α/β Ratio Variations in Cervical Cancer, with Consequent Effects on Equivalent Dose in 2 Gy Fraction in High-Dose-Rate Brachytherapy.

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Tác giả: Mark Bernard, Dennis Cheek, William St Clair, Denise Fabian, Wei Luo, Cameron Thayer-Freeman, Brien Washington

Ngôn ngữ: eng

Ký hiệu phân loại: 372.472 Strategies using standardized materials

Thông tin xuất bản: United States : Advances in radiation oncology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 684459

PURPOSE: To determine the distributions of published α/β values measured in vitro and the resulting uncertainties in the equivalent dose in 2 Gy fractions (EQD METHODS AND MATERIALS: An analysis of 98 published α/β values from 31 papers was conducted, spanning 23 cervical cancer cell lines. Values were further divided into squamous cell carcinoma and adenocarcinoma histologies. Probability distributions were fit to histograms using the bootstrapped Kolmogorov-Smirnov goodness-of-fit test. Both average and most probable α/β values for cervical cancer were determined. The probability distributions were then applied to three representative external beam therapy (EBT) plus HDR brachytherapy prescriptions to determine the potential impact they would have on the equivalent dose in 2 Gy fractions (EQD RESULTS: Published results of α/β values ranged from 1.06 to 34.3 Gy. A right-skewed log-normal distribution was shown to be the best fit for overall α/β values as well as for squamous cell carcinoma and adenocarcinoma subtypes.. Average α/β values were determined to be 8.05, 8.47, and 6.60 Gy for the total, squamous cell carcinoma, and adenocarcinoma groups, respectively. The most probable values were 4.25, 4.34, and 4.22 Gy, respectively. The variations in α/β values led to uncertainties of -8.0 to 46.4 Gy in EQD CONCLUSION: There was large variation in
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