BACKGROUND: Raising autistic children poses a daunting task for their caregivers. Providing care may take a toll on caregivers' physical, psychological, social, and financial wellbeing. This study explored the experience of the responsibility of care among caregivers of autistic children in Nigeria and informed targeted psychosocial support interventions. METHODS: This phenomenology qualitative study was conducted among 103 caregivers in Cross River, Nigeria. The PREPARE tool was used for the data collection. Data were analyzed using the inductive and deductive approaches qualitatively, using NVivo software. RESULTS: Stigma and misunderstanding of autism, emotional impact and acceptance, transportation and accessibility, lack of support networks, and balancing responsibilities and care responsibilities with personal commitments were the major challenges reported by our participants. These factors contributed to emotional strain, underscoring the complexities associated with caregiving experiences. CONCLUSION: Given the significant responsibilities of caregivers, targeted intervention must be taken to properly enlighten Nigerian societies on autistic people, and the need for acceptance. Key stakeholders must provide suitable healthcare facilities and resources for autistic people. Also, social support groups would help establish a sense of belonging and support.