Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture.

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Tác giả: Maria Camilla Ciardulli, Marta Clerici, Tina P Dale, Giovanna Della Porta, Nicholas R Forsyth, Emanuele Giordano, Erwin Pavel Lamparelli, Joseph Lovecchio, Nicola Maffulli

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Artificial cells, nanomedicine, and biotechnology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 684663

Tendon injuries significantly impact quality of life, prompting the exploration of innovative solutions beyond conventional surgery. Extracellular Vesicles (EVs) have emerged as a promising strategy to enhance tendon regeneration. In this study, human Tendon Stem/Progenitor Cells (TSPCs) were isolated from surgical biopsies and cultured in a Growth-Differentiation Factor-5-supplemented medium to promote tenogenic differentiation under static and dynamic conditions using a custom-made perfusion bioreactor. Once at 80% confluence, cells were transitioned to a serum-free medium for conditioned media collection. Ultracentrifugation revealed the presence of vesicles with a 10
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