Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development.

• Tác giả: Diaaeldin I Abdallah, Elvin D de Araujo, Patrick T Gunning, Lina S Hasan, Johan Israelian, Jeffrey W Keillor, Naman H Patel, Bilal Saqib, Timothy B Wright
• Ngôn ngữ: eng
• Ký hiệu phân loại: 006.69 Special topics in computer graphics
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 684732

Tóm tắt

Targeted protein degradation (TPD) is revolutionizing drug discovery, but PROTAC synthesis remains challenging due to multi-step synthesis and slow linker installation