Disagreements over conflicting viewpoints are common and have important implications for social relationships and overall well-being. A large corpus of research from the political and social sciences documents the myriad negative consequences of disclosing dissenting viewpoints. However, relatively less is known about how sharing (and encountering) opposing viewpoints impacts real-time affective, physiological, and behavioral processes. Toward this end, this research manipulated the beliefs, values, and opinions held by an opposing other in a novel dyadic context to (a) examine ongoing processes during interpersonal disagreements and (b) establish an immersive paradigm to experimentally study interpersonal disagreement (vs. agreement). Participants (