OBJECTIVE: Aim: To investigate the effectiveness of a therapeutic and prophylactic complex based on mineral metabolism markers in a peri-implantitis model under calcium deficiency conditions.. PATIENTS AND METHODS: Materials and Methods: A peri-implantitis under calcium deficiency was modeled in experimental animals. The study evaluated the effects of a therapeutic and prophylactic complex, consisting of the oral gel "Perioimplantgel" and the dietary supplement "Minerol," on markers of mineral metabolism in the blood and periodontal tissues of rats. RESULTS: Results: Modeling peri-implantitis in experimental animals with calcium deficiency caused a significant decrease in magnesium, calcium, and phosphorus levels in the blood and periodontal tissues, accompanied by increased osteoresorption and alkaline phosphatase activation. The oral gel "Perioimplantgel" significantly reduced enzyme activity, while the combination with the dietary supplement "Minerol" stabilized all mineral metabolism markers, returning tchem to levels comparable to intact animals. These effects were more pronounced with prolonged use of the complex before and after implantation, suggesting its high osteoregenerative properties and the need for extended use. CONCLUSION: Conclusions: The applied experimental model of peri-implantitis in the conditions of calcium deficiency allowed for revealing the positive effect of the oral gel "Perioimplantgel" on the state of periodontal tissues during the installation of dental implants, as well as determining the indicators of mineral metabolism for its greatest effectiveness when used in combination with the dietary supplement "Minerol".