Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain.

• Tác giả: Thomas Burgoyne, Chiara Cecconello, Miguel Á Huerta, Marzia Malcangio, Silvia Oggero, Mauro Perretti, Francesca Picco, Mathieu-Benoit Voisin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.133349 Aerospace engineering
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 685217

Tóm tắt

Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather than at the site of inflammation plays mechanistic roles in persistent arthritis pain. Here, we inhibited production of proresolving lipid mediators by silencing 12/15-lipoxygenase expression in CX3CR1