PURPOSE: F13640 is a highly selective serotonin 5-HT METHODS: Test-retest PET-MRI scans of 225 min were conducted in eight healthy male volunteers. For 17 brain regions, distribution volume ratios (DVR) were calculated from the whole kinetics using Logan plot modelling method with the cerebellum white matter as reference region. For the same regions, SUVR were also calculated from static images, for four 20-minute and four 10-minute time-intervals at various time of uptake. Reliability between SUVR and DVR measures were studied, and test-retest parameters were assessed between PET sessions for each time-interval. RESULTS: Reproducibility of measures of SUVR compared to DVR were excellent, whatever the time interval (p <
0.001). For the 20-min. time-intervals, SUVR CONCLUSION: This study confirms the feasibility of static acquisitions to facilitate clinical use of the [