Parishin A alleviates insomnia by regulating hypothalamic-pituitary-adrenal axis homeostasis and directly targeting orexin receptor OX

• Tác giả: Su An, Hao Chen, Xiaoxi Guo, Mengli Lan, Cheng Xiang, Tian-Rui Xu, Xiuyu Yang, Yang Yang, Yue Yu, Lijing Zhang, Huanchun Zhao, Ya Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : European journal of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 685562

Tóm tắt

Parishin A (PA), a bioactive compound derived from Gastrodia elata Blume, has been used as a herbal remedy for insomnia. Nevertheless, the mechanism underlying the effect of PA on promotion of sleep and its potential targets remain to be elucidated. This study aimed to investigate the potential of PA in ameliorating insomnia, probing into its interactions with the orexin receptor 2 (OX