OBJECTIVE: This study examined the relationship between a mandatory attendance policy (MAP) and grade point average (GPA), grade distribution, and course failures in a Doctor of Pharmacy program. Student adherence to the MAP was described. METHODS: A MAP was implemented in academic year 2021-2022. Pre- and post-MAP course grades were collected retrospectively, as were post-MAP attendance records and violations for MAP nonadherence. Due to curricular revisions, grade analyses were restricted to first and third years. RESULTS: Analysis of Covariance (ANCOVA) revealed significant main and interaction effects for MAP and curriculum on unweighted GPA. Specifically, unweighted third-year GPA increased by 0.21 points post-MAP, and unweighted first-year GPA increased by 0.11 points. The MAP had a greater impact in the third year than first based on the significant interaction effect. For weighted GPA, ANCOVA revealed a significant main effect for MAP and no main effect for curriculum or interaction effect. Specifically, there was a significant increase of 0.14 GPA points for the aggregate first- and third-year weighted GPA post-MAP. For final grades in third-year courses, failures decreased significantly from 1.04% pre-MAP to 0.31% post-MAP, and likewise for first-year courses, from 3.14% pre-MAP to 1.73% post-MAP. For both years, grades improved at the upper and lower ends of the distributions, post-MAP. Student body MAP adherence in the two academic years post-MAP ranged from 93.2% in fall 2021 to 79.6% in spring 2023. CONCLUSION: Implementation of a MAP warrants consideration by schools and colleges of pharmacy seeking to improve students' academic performance.