Cross-sectional associations between clinical biochemistry and nutritional biomarkers and sarcopenic indices of skeletal muscle in the Baltimore Longitudinal Study of Aging.

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Tác giả: Donnie Cameron, Luigi Ferrucci, Jamie Scott, Toshiko Tanaka, Ailsa A Welch, Max Yates

Ngôn ngữ: eng

Ký hiệu phân loại: 272.3 Persecutions of Waldenses and Albigenses

Thông tin xuất bản: United States : The Journal of nutrition , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 685624

BACKGROUND: Investigating relationships between nutritional and clinical biochemistry biomarkers and skeletal muscle mass, strength and function (sarcopenic indices) may: (i) highlight micronutrients of interest for potential preventive or treatment strategies for sarcopenia, or (ii) highlight biomarkers that may be useful for identifying individuals at risk of sarcopenia. OBJECTIVES: Investigate associations between nutritional biomarkers (vitamin D, vitamin B12, folate, magnesium, potassium, calcium, iron), clinical biomarkers (haemoglobin, ferritin, albumin, creatinine, HbA1c) and sarcopenic indices (appendicular lean mass (ALM), height-adjusted ALM (ALM DESIGN: Using multivariable linear regression analysis we investigated cross-sectional associations between biomarkers and sarcopenic indices in data collected from 1,761 participants (age 22-103 years) from the Baltimore Longitudinal Study of Aging (BLSA). RESULTS: Haemoglobin was positively associated with ALM (β=0.20, p=0.021), HGS CONCLUSION: The associations found between measures of iron status and creatinine and sarcopenic indices, in men in particular, indicate potential importance for muscle health. Future longitudinal and intervention studies are warranted to confirm these findings.
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