Plasmidome analyses of Klebsiella pneumoniae coproducing blaKPC-2 and blaNDM-1 in Southern Brazil: Characterization of Mobile Genetic Elements.

• Tác giả: A L Barth, P O Barth, M K H Berdichevski, R M Carrassai, A P Carvalho-Assef, R R Guerra, A F Martins, D C Pereira, C Rocha-de-Souza, M C Silveira, F C Z Volpato, C M Wilhem
• Ngôn ngữ: eng
• Ký hiệu phân loại: 781.2 Elements of music
• Thông tin xuất bản: Netherlands : Journal of global antimicrobial resistance , 2025
• Bộ sưu tập: NCBI
• ID: 685640

Tóm tắt

OBJECTIVES: Infections due to carbapenemase-producing Enterobacterales harboring more than one carbapenemase-encoding gene spreads mainly by plasmid and transposon mobilization. OBJECTIVES: Analyze the mobile genetic elements carrying bla METHODS: K. pneumoniae isolates with reduced susceptibility to carbapenems were obtained from 2016 to 2023. To evaluate the genetic environment of KpKN, 22 isolates were selected for antimicrobial susceptibility testing and whole-genome sequencing (WGS). RESULTS: The bla CONCLUSIONS: The plasmid and transposon changes during the different periods could be related to higher dissemination of the bla