GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease.

• Tác giả: Angelica M Bachman, Robert F Berman, Sierra Coyne, Alyssa Frelka, Tracy L Hagemann, Ni-Hsuan Lin, Matthew R Matson, Albee Messing, Robert A Pearce
• Ngôn ngữ: eng
• Ký hiệu phân loại: 611.316 Salivary glands
• Thông tin xuất bản: United States : eNeuro , 2025
• Bộ sưu tập: NCBI
• ID: 685740

Tóm tắt

Alexander disease (AxD) is a rare neurological disorder caused by dominant gain-of-function mutations in the gene for glial acidic fibrillary protein (