With the rapid emergence of flexible electronics, flexible pressure sensors are of importance in various fields. In this study, a dopamine-modified melamine sponge (MS) was used to prepare a honeycomb structure of carbon black (CB)/MXene-silicone rubber (SR)@MS flexible pressure sensor (CMSM) through layer-by-layer self-assembly technology. Using SR as a binder to construct the honeycomb structure not only improves the mechanical properties of the sensor but also provides more attachment sites for CB/MXene, enhancing the stability of the conductive network. The honeycomb structure CMSM flexible pressure sensor exhibits high sensitivity (7.44 kPa