Investigation of anti-microbial and cytotoxic potential of Streptomyces werraensis GRS9 derived from the sediments of river Ganga.

• Tác giả: Kartikey Kumar Gupta, Deepa Malik, Himalaya Panwar, Swati Rani
• Ngôn ngữ: eng
• Thông tin xuất bản: Brazil : Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] , 2025
• Bộ sưu tập: NCBI
• ID: 686002

Tóm tắt

The aim of the present work was to screen bacterial and actinomycetes strains from the sediments of river Ganga (India) as a promising source of anti-microbial and anti-cancer agents along with spectroscopic and chromatographic identification of bio-active compounds. The strain GRS9 exhibited broad-spectrum bio-activity against all the 15-test organisms incorporated in our study with minimum inhibitory concentrations (MICs) ranging from 16 µg/ml against Staphylococcus aureus MTCC3160 to 500 μg/ml for Escherichia coli (MTCC118). The cytotoxic profile of ethyl acetate extract was also evaluated against Human Colon Cancer Cell Line (HCT116) by Neutral Red Uptake (NRU) assay, followed by in silico study to determine its pre-qualification for drug suitability. The results indicated that Streptomyces werraensis GRS9 extract possessed anti-cancer properties (IC