Mitochondrial Involvement in the Pathogenesis of Endometriosis and its Potential as Therapeutic Targets.

• Tác giả: PanWei Hu, Jing Li, Cong Qi, DongYi Shen, YingHong Shen
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Reproductive sciences (Thousand Oaks, Calif.) , 2025
• Bộ sưu tập: NCBI
• ID: 686021

Tóm tắt

Endometriosis is an estrogen-dependent benign disease characterized by the development of endometrial tissue outside the uterus. This intricate ailment markedly affects a patient's well-being and lacks a definitive cure. Endometriotic cells enhance their viability by modulating genetic and epigenetic characteristics, with mitochondria being important organelles in determining cellular metabolic pathways. Mitochondrial malfunction is associated with various human disorders, and the disruption of mitochondrial adaptation mechanisms may help develop new therapies for endometriosis. This article examines the significance of mitochondrial balance in the etiology and advancement of endometriosis and introduces several potential drugs targeting mitochondria for its treatment.