TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling.

• Tác giả: Severine Cathelin, Steven M Chan, Mohsen Hosseini, Alex C H Liu, Abdula Maher, Dhanoop Manikoth Ayyathan, Amit Subedi, Robert Vanner, Yitong Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 614.5128 Incidence of and public measures to prevent specific diseases and kinds of diseases
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 686095

Tóm tắt

Ten-Eleven Translocation-2 (TET2) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which TET2 mutations confer a competitive advantage to HSCs remain unclear. Here, through an epigenetic drug screen, we discover that inhibition of disruptor of telomeric silencing 1-like (DOT1L), a H3K79 methyltransferase, selectively reduces the fitness of Tet2 knockout (Tet2