Suppression of stress granule formation is a vulnerability imposed by mutant p53.

• Tác giả: Dan A Dixon, Tomoo Iwakuma, Shigeto Nishikawa, Sugako Oka, Alejandro Parrales, Atul Ranjan, Elizabeth Thoenen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 546.677 *Indium
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 686126

Tóm tắt

Missense mutations in the TP53 (p53) gene have been linked to malignant progression. However, our in-silico analyses reveal that hepatocellular carcinoma (HCC) patients with mutant p53 (mutp53) have better overall survival compared to those with p53-null (p53