Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer.

• Tác giả: Adel Benlahrech, Anna Broomfield, Antonio Camera, James Clubley, Laura Collins, Luis Del Carpio, Esra Güç, Jessica C Hassel, Holger Heyn, Anastasiya Kazachenka, Rahul Khanolkar, Emma Leach, Paula Nieto Garcia, Josep M Piulats, Koustubh Ranade, Joseph J Sacco, Sarah Stanhope, Agatha Treveil
• Ngôn ngữ: eng
• Ký hiệu phân loại: 780 Music
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 686129

Tóm tắt

Uveal melanoma (UM) is the most common intraocular cancer in adults, with metastatic disease (mUM) occurring in approximately half of the patients. Tebentafusp, an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC), is a therapeutic shown to improve overall survival (OS) in HLA-A*02:01