Protein disulfide isomerase is essential for osteoblast differentiation in mice.

• Tác giả: Yue Han, Yue Lu, Depei Wu, Yi Wu, Aizhen Yang, Zhenzhen Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 946.7 *Eastern Spain and Andorra
• Thông tin xuất bản: England : Communications biology , 2025
• Bộ sưu tập: NCBI
• ID: 686151

Tóm tắt

Protein disulfide isomerase (PDI) is an oxidoreductase responsible for the formation, reduction and isomerization of disulfide bonds of nascent proteins in endoplasmic reticulum (ER). So far, the role of PDI in bone biology has never been characterized using genetically-modified animal models. In this study we generated osteoblast- specific PDI-deficient mice by crossing PDI-floxed (PDI