Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice.

• Tác giả: Nandini Acharya, Qian Cao, Weiyu Chen, Bijun Cui, Yimin Ding, Hongshan Guo, Ke Guo, Yu Hou, Youling Huang, Hui Li, Shumin Li, Tong Liu, Yunkun Lu, Ting Pan, Wang Qingqing, Min Shang, Manlu Shen, Shuying Shen, Zhida Shen, Kai Wang, Pinli Wang, Zhenzhen Wen, Peng Xiao, Junjie Xu, Xutao Xu, Yuening Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 686180

Tóm tắt

Overcoming immunosuppression in the tumor microenvironment (TME) is crucial for developing novel cancer immunotherapies. Here, we report that IL-16 administration enhances the polarization of T helper 1 (Th1) cells by inhibiting glutamine catabolism through the downregulation of glutaminase in CD4