Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.

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Tác giả: Al-Murtadha Al-Gahmi, Syed Muntazir Andrabi, Milton E Busquets, Mark A Carlson, Carlos Poblete Jara, Alec D McCarthy, Mallory I Nilles, S M Shatil Shahriar, Navatha Shree Sharma, Chenlong Wang, Jingwei Xie, Zishuo Yan, Kai Yang, Zakariya A Yusuf

Ngôn ngữ: eng

Ký hiệu phân loại: 651.504 Special topics of records management

Thông tin xuất bản: England : Nature communications , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 686280

Managing junctional hemorrhage is challenging due to ineffective existing techniques, with the groin being the most common site, accounting for approximately 19.2% of potentially survivable field deaths. Here, we report a bicomponent nano- and microfiber aerogel (NMA) for injection into deep, narrow junctional wounds to effectively halt bleeding. The aerogel comprises intertwined poly(lactic acid) nanofibers and poly(ε-caprolactone) microfibers, with mechanical properties tunable through crosslinking. Optimized aerogels demonstrate improved resilience, toughness, and elasticity, enabling rapid re-expansion upon blood contact. They demonstrate superior blood absorption and clotting efficacy compared to commercial products (i.e., QuikClot® Combat Gauze and XStat®). Most importantly, in a lethal swine junctional wound model (Yorkshire swine, both male and female, n = 5), aerogel treatment achieved immediate hemostasis, a 100% survival rate, no rebleeding, hemodynamic stability, and stable coagulation, hematologic, and arterial blood gas testing.
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