miR-708-5p is elevated in bipolar patients and can induce mood disorder-associated behavior in mice.

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Tác giả: Alessandra Lo Bianco, Silvia Bicker, Udo Dannlowski, Pierre-Luc Germain, Carlotta Gilardi, Fridolin Gross, Tilo Kircher, Theresa M Kisko, Brunno Rocha Levone, Helena C Martins, Susanne Meinert, Gerhard Schratt, Rainer K W Schwarting, Frederike Stein, Ayse Özge Sungur, Markus Wöhr

Ngôn ngữ: eng

Ký hiệu phân loại: 946.7 *Eastern Spain and Andorra

Thông tin xuất bản: England : EMBO reports , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 686345

Mood disorders (MDs) are caused by an interplay of genetic and environmental (GxE) risk factors. However, molecular pathways engaged by GxE risk factors are poorly understood. Using small-RNA sequencing in peripheral blood mononuclear cells (PBMCs), we show that the bipolar disorder (BD)-associated microRNA miR-708-5p is upregulated in healthy human subjects with a high genetic or environmental predisposition for MDs. miR-708-5p is further upregulated in the hippocampus of rats which underwent juvenile social isolation, a model of early life stress. Hippocampal overexpression of miR-708-5p in adult male mice is sufficient to elicit MD-associated behavioral endophenotypes. We further show that miR-708-5p directly targets Neuronatin (Nnat), an endoplasmic reticulum protein. Restoring Nnat expression in the hippocampus of miR-708-5p-overexpressing mice rescues miR-708-5p-dependent behavioral phenotypes. Finally, miR-708-5p is upregulated in PBMCs from patients diagnosed with MD. Peripheral miR-708-5p expression allows to differentiate male BD patients from patients suffering from major depressive disorder (MDD). In summary, we describe a potential functional role for the miR-708-5p/Nnat pathway in MD etiology and identify miR-708-5p as a potential biomarker for the differential diagnosis of MDs.
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