A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.

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Tác giả: Srdjan Cirovic, Ryan Jones, Clare Rusbridge

Ngôn ngữ: eng

Ký hiệu phân loại: 306.74082 Sexual relations

Thông tin xuất bản: England : Fluids and barriers of the CNS , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 686487

Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation of CSF flow can lead to conditions like syringomyelia, and hydrocephalus. This review details the anatomy of CSF flow, examining its contribution to waste clearance within the brain and spinal cord. The review integrates data from human, canine, and other mammalian studies, with a particular focus on brachycephalic dogs. Certain dog breeds exhibit a high prevalence of CSF-related conditions due to artificial selection for neotenous traits, making them valuable models for studying analogous human conditions, such as Chiari-like malformation and syringomyelia associated with craniosynostosis. This review discusses the anatomical features specific to some brachycephalic breeds and the impact of skull and cranial cervical conformation on CSF flow patterns, providing insights into the pathophysiology and potential modelling approaches for these conditions.
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