BACKGROUND AND PURPOSE: The risk factors for developing epilepsy following febrile convulsion (FC) have been studied extensively, but the underlying genetic components remain largely unexplored. Our objective here was to identify the risk loci related to FC through a genome-wide association study of Korean epilepsy patients. METHODS: We examined associations between a history of FC and single-nucleotide polymorphisms (SNPs) in data obtained from 125 patients with focal epilepsy: 28 with an FC history and 97 without an FC history. RESULTS: Among 288,394 SNPs, 5 candidate SNPs showed CONCLUSIONS: This novel discovery of SNPs upstream of