PURPOSE: This study aimed to evaluate the surgical management and long-term follow-up of hypotony related to post-vitrectomy peripheral circumferential retinal detachment (PCD). METHODS: Eyes diagnosed with hypotony secondary to PCD after pars plana vitrectomy were retrospectively reviewed. The patient demographic data, complications, management, and treatment outcomes were collected and analyzed. RESULTS: Four eyes were included in this study. The median preoperative best-corrected visual acuity (BCVA) was 20/200 and the mean preoperative intraocular pressure (IOP) was 4.5 mmHg. One case had rubeosis iridis. All eyes underwent peripheral retinectomy to remove the detached retina and release ciliary body traction. Complete retinal reattachment was achieved in all eyes. The final BCVA ranged from 20/200 to 20/50 and regression of rubeosis iridis was observed. Mean IOP improved to 12,25 mmHg at 12 months after the retinectomy. The mean follow- up time was 5 years (range 2-7 years). CONCLUSION: Aggressive dissection and 360º trimming of the anterior retina is helpful to relieve ciliary body traction and remove ischemic tissue, restoring minimally adequate aqueous production in cases of hypotony related to PCD. TRIAL REGISTRATION: This retrospective study was approved by the Institutional Review Board, under registration number 77599724.7.0000.0068.