Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.

• Tác giả: Jie Feng, Silu Liu, Yaping Luo, Qingqing Pan, Hongzhe Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 614.45 Patient isolation
• Thông tin xuất bản: United States : Clinical nuclear medicine , 2025
• Bộ sưu tập: NCBI
• ID: 686751

Tóm tắt

A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.