[The role of microglia activated by the deletion of immune checkpoint receptor CD200R1 gene in a mouse model of Parkinson's disease].

• Tác giả: Xiao-Li Gong, Xarbat Gongbikai, Jia-Li Guo, Tao-Ying Huang, Kun Niu, Xiao-Min Wang, Ting Zhang, Zhen Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: China : Sheng li xue bao : [Acta physiologica Sinica] , 2025
• Bộ sưu tập: NCBI
• ID: 686794

Tóm tắt

The study aimed to investigate the effect of the CD200R1 gene deletion on microglia activation and nigrostriatal dopamine neuron loss in the Parkinson's disease (PD) process. The CRISPR-Cas9 technology was applied to construct the CD200R1