[The regulation and mechanism of apolipoprotein A5 on myocardial lipid deposition].

• Tác giả: Jing-Yuan Chen, Wen-Jie Chen, Yu-Si Chen, Jiang Li, Jun Luo, Xiao-Qin Luo, Hai-Hua Qiu, Xiao-Jie Yang, Teng-Teng Zhu
• Ngôn ngữ: eng
• Thông tin xuất bản: China : Sheng li xue bao : [Acta physiologica Sinica] , 2025
• Bộ sưu tập: NCBI
• ID: 686798

Tóm tắt

The current study aimed to clarify the roles of apolipoprotein A5 (ApoA5) and milk fat globule-epidermal growth factor 8 (Mfge8) in regulating myocardial lipid deposition and the regulatory relationship between them. The serum levels of ApoA5 and Mfge8 in obese and healthy people were compared, and the obesity mouse model induced by the high-fat diet (HFD) was established. In addition, primary cardiomyocytes were purified and identified from the hearts of suckling mice. The 0.8 mmol/L sodium palmitate treatment was used to establish the lipid deposition cardiomyocyte model