Halogenated antibiotics pose a great threat to aqueous environments because of their persistent biotoxicity from carbon-halogen bonds. Electrochemical reduction (ER) is an efficient technology for dehalogenation, but it still suffers from limited efficiencies in breaking C-F bonds. Herein, we present a strategy to enhance C-F cleavage and promote detoxification by loading benchmark palladium cathodes onto boron-doped carbon. This improves the florfenicol (FLO) degradation rate constant and defluorination efficiency by 1.24 and 1.05 times, respectively, and improves the defluorination of various fluorinated compounds. The cathode with optimal B content shows superior mass activity for FLO degradation (1.11 mmol g