Post-extubation stridor poses a significant challenge in critical care settings, often necessitating prompt intervention to prevent respiratory compromise and potential reintubation. This case report details the successful management of post-extubation stridor in a 55-year-old female patient with a complex medical history, using heliox therapy. Heliox, a gas mixture of helium and oxygen, has emerged as a novel therapeutic option in such scenarios, owing to its ability to reduce airway resistance and improve gas flow dynamics. Following the patient's elective intubation for MRI imaging, she developed hoarseness, loud breathing, and stridor upon extubation, indicative of subglottic edema and bilateral vocal cord paralysis. Despite initial treatment with conventional modalities yielding minimal improvement, heliox therapy (70%/30%) with supplemental oxygen was initiated, resulting in significant alleviation of symptoms. Subsequent maintenance therapy with corticosteroids and bronchodilators further facilitated the resolution of respiratory distress. This case underscores the pivotal role of heliox therapy as an effective adjunct in managing post-extubation stridor, offering rapid relief and potentially obviating the need for reintubation. Moreover, it highlights the importance of innovative therapeutic approaches in optimizing outcomes for patients with respiratory distress in critical care settings. However, further research is warranted to elucidate the optimal utilization criteria and long-term efficacy of heliox therapy in this context.