Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States.

• Tác giả: Min Cui, Xiuju Guan, Wenjun Jia, Xiandu Jin, Yue Liu, Xin Qi, Liping Wei, Hao Wu, Ruohang Xu, Hanmo Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.45193 Ordnance
• Thông tin xuất bản: New Zealand : Journal of inflammation research , 2025
• Bộ sưu tập: NCBI
• ID: 686983

Tóm tắt

BACKGROUND: The systemic immune-inflammatory index (SII) serves as a comprehensive indication of systemic inflammation. However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated. METHODS: A total of 2727 patients with CAD were enrolled between January 2018 and April 2022. SII was calculated as (platelet count × neutrophil count)/lymphocyte count. Participants were grouped by SII quartiles. Glucose metabolic status was classified as normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM) and diabetes mellitus (DM) according to World Health Organization guidelines. Logistic regression and restricted cubic spline models were applied to estimate the relationship between SII and severity of coronary artery lesions in different glucose metabolic states with further adjustments for confounders. RESULTS: Logistic regression analysis indicated a significant association between SII and coronary lesion severity ( CONCLUSION: The SII is a relatively stable indicator of inflammation and is positively correlated with coronary lesion severity. This study highlights the potential of SII as a novel inflammatory biomarker for assessing the coronary lesion severity among patients in different glucose metabolic states.