Development of a novel anti-erythropoietin-producing hepatocellular receptor B6 monoclonal antibody Eb

• Tác giả: Shiori Fujisawa, Mika K Kaneko, Yu Kaneko, Yukinari Kato, Guanjie Li, Takuya Nakamura, Hiroyuki Satofuka, Keisuke Shinoda, Hiroyuki Suzuki, Tomohiro Tanaka, Haruto Yamamoto
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: Netherlands : Biochemistry and biophysics reports , 2025
• Bộ sưu tập: NCBI
• ID: 687093

Tóm tắt

Erythropoietin-producing hepatocellular receptor B6 (EphB6) is a member of the largest Eph subfamily of receptor tyrosine kinases. EphB6 is widely expressed in various tissues and regulates cellular homeostasis by interacting with its membrane-bound ephrin ligands and other receptors. EphB6 is involved in cancer pathology despite lacking kinase activity. Developing sensitive monoclonal antibodies (mAbs) for EphB6 has been desired for treatment, diagnosis, and further analysis of EphB6. This study established a novel specific and sensitive anti-human EphB6 mAb clone Eb