Ni(ii)/spiroBox-catalyzed asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes.

• Tác giả: Guorui Cao, Nanxing Gao, Luzhen Jiao, Yanshun Li, Shiqin Sun
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.50882 Astrology
• Thông tin xuất bản: England : RSC advances , 2025
• Bộ sưu tập: NCBI
• ID: 687151

Tóm tắt

Nickel complexes of chiral spiroBox ligand catalyzed Friedel-Crafts alkylation reaction of indoles with nitroalkenes. Excellent yields (up to 99%) and enantiomeric excess (ee) values (up to 97%) were obtained with a broad scope of substrates. This catalytic system provides a facile synthesis of optically active 2-indolyl-1-nitro derivatives with high yield and enantioselectivity.