BACKGROUND: Visceral fat accumulation and dyslipidaemia are associated with infertility symptoms. The cardiometabolic index (CMI) is a comprehensive quantitative measure of central obesity and dyslipidaemia. However, the link between the female CMI and the couple infertility needs to be explored further. Hence, this study aimed to dissect this connection. METHODS: The study used a cross-sectional approach to select 1,641 female participants from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2013 and 2020. The natural log-transformed CMI (In-CMI) was used to consider the non-normal distribution of CMI. Logistic regression models adjusted for covariates were employed to investigate the association between the In-CMI and couple infertility. RESULTS: After adjusting for all covariates, each 1 unit increase in the In-CMI was associated with a 34% increase in the incidence of infertility (odds ratio [OR] 1.34, 95% confidence interval [CI] 1.10-1.64, CONCLUSION: The female CMI is linked to the incidence of couple infertility. Moreover, the female CMI shows significant medical significance for assessing couple infertility risk of childbearing age.