Halophiles produce extraordinarily stable enzymes under conditions where conventional enzymes cease to function, denature, and precipitate. Halophilic enzymes have adapted to function optimally at high salt concentrations besides tolerance of organic solvents and thermal stability. These special features offer potential advantages of cost-effectiveness and improved treatment outcomes that make them valuable for pharmaceutical purposes including the synthesis, design, and discovery of new drugs. The article highlights the unique characteristics and adaptation strategies of halophiles towards salinity. It provides an overview of halophilic enzymes' pharmaceutical applications and examines different challenges, opportunities, and recent advances in applying these enzymes in this field.