Ocular melanoma encompasses the uveal tract, conjunctiva, eyelid, and orbit. Palpebral localization is extremely infrequent, constituting less than 1% of skin melanomas, the main treatment of which is surgical. However, the radicality of the resection is restricted by anatomical location and functional sequelae. The importance of obtaining free surgical margins, which impact the percentage rate of locoregional recurrence and patient survival, has led to recommendations regarding the distance of the margin in the macroscopic (5 mm) and microscopic (>
2 mm) evaluation, as well as the use of Mohs surgical technique for selected groups. Adequate surgical and reconstructive planning are the main objectives of multidisciplinary management in these patients. We present the case of a patient with palpebral melanoma treated in an oncology unit in Latin America.