BACKGROUND AND AIM: HIV attacks the immune system, leading to AIDS if untreated. Mpox, a zoonotic disease like smallpox, is less severe but poses higher risks for immuno-compromised individuals, especially those with HIV. Effective prevention and treatment are crucial. This study aims to assess the global academic output on Monkeypox (MPVX) and HIV during 2018-2023. METHODS: This descriptive, bibliometric study reviewed the published literature on "monkeypox" and "HIV" during the period 2018-2023. The search was conducted on February 11, 2024, using a systematic formula. We identified 366 potential articles, including various types of papers. When exporting metadata to SciVal for the period 2018-2023, 8 metadata could not be exported. The remaining data were analyzed using SciVal and Bibliometrix in R Studio, providing an overview of research productivity, collaborations, and citation impact. RESULTS: During the period 2018-2023, 366 papers on "monkeypox" and "HIV" were published in 183 different sources, with an annual growth rate of 208.18%. These papers had an average of 14.78 citations per paper. An additional 2522 keywords and 638 author keywords were identified. The " CONCLUSION: Research on Monkeypox and HIV has grown significantly during the period studied, with remarkable international collaboration. These findings underscore the importance and global impact of Monkeypox and HIV research.